Issues in biochemical applications to risk assessment: how do we predict toxicity of complex mixtures?
نویسنده
چکیده
Predicting the toxicity of mixtures is an important current problem, and I'll talk about my personal view of the matter. I think that there are two broad classes of mixtures, one of which is the disposal mixtures: things that go into dump sites. These are highly variable from one site to another, since they depend on specific industrial operations, and it's difficult to extrapolate from site to site. The other class is the complex mixture from defined processes, such as combustion processes: automobile emissions, emissions from power plants, cigarette smoke, and so on. I think the current approach to predicting the toxicity of complex mixtures is thoroughly empirical, and I don't know of any ways of doing things other than the way they're actually being done. Namely, with disposal mixtures, such as those occurring in dump sites, one summates the risk from individual agents for which one has existing data and ignores the possibility of interactions. It is recognized that this approach may be inadequate, but the problem of doing bioassays on individual dump sites is so expensive as to be daunting. The situation which, in many respects, is easier is the
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عنوان ژورنال:
- Environmental Health Perspectives
دوره 76 شماره
صفحات -
تاریخ انتشار 1987